Manhattan Regional Airport provides Commercial Airline and General Aviation services to customers in the Flint Hills region. The region encompasses an area within a 60-minute drive of the airport, touches 12 counties, and contains an approximate population base of 250,000 people. Daily scheduled airline service connects passengers to Dallas/Fort Worth International Airport and Chicago-O'Hare International Airport. The airport records over sixty-thousand passenger enplanements annually.

General Aviation Services include air charter, air cargo, flight instruction, air photo, major aircraft maintenance, aircraft refueling, tie-down, and aircraft storage. Jet charters supporting Fort Riley and Kansas State University frequent the airport. There are over 40 aircraft based at the airport. The Airport is classified by the Federal Aviation Administration as a Primary Commercial Service, Non-hub airport in the National Plan of Integrated Airport Systems (NPIAS).